High-Resolution Array CGH and Gene Expression Profiling of Alveolar Soft Part Sarcoma

Human Cancer Biology High-Resolution Array CGH and Gene Expression Profiling of Alveolar Soft Part Sarcoma

Purpose: Alveolar soft part sarcoma (ASPS) is a soft tissue sarcoma with poor prognosis, and little molecular evidence exists for its origin, initiation, and progression. The aim of this study was to elucidate candidate molecular pathways involved in tumor pathogenesis. Experimental Design: We employed high-throughput array comparative genomic hybridization (aCGH) and cDNA-Mediated Annealing, S...

High-resolution array CGH and gene expression profiling of alveolar soft part sarcoma.

PURPOSE Alveolar soft part sarcoma (ASPS) is a soft tissue sarcoma with poor prognosis, and little molecular evidence exists for its origin, initiation, and progression. The aim of this study was to elucidate candidate molecular pathways involved in tumor pathogenesis. EXPERIMENTAL DESIGN We employed high-throughput array comparative genomic hybridization (aCGH) and cDNA-Mediated Annealing, S...

Molecular Profiling of Alveolar Soft Part Sarcoma 1 High resolution array CGH and gene expression profiling of alveolar soft part sarcoma

Metastasis of alveolar soft part sarcoma of the retroperitoneum to distal phalanx of hand

Hand metastasis accounts for approximately 0.1 percent of all metastatic osseous malignancies. The lung, breast and kidney are the most common primary sources of these metastatic lesions.A rare case of retroperitoneal alveolar soft part sarcoma metastasizing to the distal phalanx of the second finger of the right hand is presented here. The patient underwent complete DIP amputation of the affec...

Angiogenesis-promoting gene patterns in alveolar soft part sarcoma.

PURPOSE We examined a cohort of patients with alveolar soft part sarcoma (ASPS) treated at our institution and showed the characteristic ASPSCR1-TFE3 fusion transcript in their tumors. Investigation of potential angiogenesis-modulating molecular determinants provided mechanistic and potentially therapeutically relevant insight into the enhanced vascularity characteristic of this unusual tumor. ...